 |  The City of Greenville and the surrounding area host a wide array of churches of various denominations:
Advent Christian  | Church of Christ, 1416 IL RT 140,
618-664-1288 | | | | Apostolic | | First Apostolic Church, 901 E. City Route 40,
618-664-1451 | | | | Assemblies of God | | Calvary Temple, 1111 E. College Ave.,
618-664-2852 | | | Baptist | | First Baptist Church (American USA), 218 E. South Ave., 618-664-1062 Smith Grove Baptist Church (Southern), 949 Airport Ave., 618-664-4177 | |
| | Catholic | | Saint Lawrence Church, 512 South Prairie St., 618-664-3169 | | | | Christian | | Central Christian Church, 205 S. Prairie, 618-664-0802 | | First Christian Church, 1100 Killarney Dr., 618-664-0350 | | | | Church of Christ | | Church of Christ, 1416 IL Hwy 140 E., 618-664-1288 | | | | Free Methodist | | Greenville Free Methodist Church, 1367 E. State Route 140, 618-664-2584 | | Free Methodist Church - Gateway Conference, 114 N. 2nd St., 618-664-2353 | | St. Paul's Free Methodist Church, 813 E. College Ave., 618-664-2159 | | | | Jehovah's Witness | | Greenville Congregation of Jehovah's Witnesses, 632 Illinois Route 127, 618-664-9643 | | | | Lutheran | | Our Redeemer Lutheran Church, 1540 E. State Route 140, 618-664-0223 | | | | Presbyterian (USA) | | First Presbyterian, 501 Idler Ln., 618-664-0942 | | | | Southern Baptist | | Wisetown Baptist Church, 173 Wisetown Road, 618-664-3744 | | | | United Church of Christ | | St. Peters United Church of Christ, 1670 Hookdale Lane, 618-664-2129 | | | | United Methodist | | First United Methodist Church, 310 S. 2nd St., 618-664-1566 |
| Non-Denominational | | Cross of Victory, 793 US Route 40, 618-664-4980 | | Mount Zion Temple of Deliverance and Praise, 201 S. Fourth Street, 618-664-3016 |
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